What does this research mean for the field?

Protein post-translational modifications (PTMs) play a key regulatory role in the pathogenesis of ulcerative colitis by modulating immune function, epithelial integrity, and inflammatory signaling, and represent promising therapeutic targets. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Summarize the regulatory mechanisms and biological roles of protein post-translational modifications in the pathogenesis of ulcerative colitis.

August 30, 2026Molecular Biology ReportsOpen Access

The regulatory role of post-translational modifications in the pathogenesis of ulcerative colitis

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Authors

YJYuan JiJiangxi Provincial Cancer Hospital BWBajin WeiFirst Affiliated Hospital Zhejiang University

Discussion

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Implication

Review uncovers the regulatory roles of post-translational modifications in ulcerative colitis, highlighting novel therapeutic targets for gut mucosal inflammation.

Key Points

Summarize the regulatory mechanisms and biological roles of protein post-translational modifications in the pathogenesis of ulcerative colitis.
Conducted a comprehensive review evaluating the role of protein post-translational modifications in ulcerative colitis etiology.
Synthesized evidence across multiple modification pathways, including phosphorylation, glycosylation, acetylation, methylation, ubiquitination, citrullination, and palmitoylation.
Post-translational modifications critically govern protein activity, structural stability, intracellular signaling networks, and intestinal cellular homeostasis.
Dysregulated modifications impair colonic epithelial barrier integrity and trigger aberrant immune and inflammatory signaling pathways.
Elucidating aberrant post-translational modification networks identifies promising candidate targets for future ulcerative colitis therapeutics.

Cite This Study

Ji et al. (2026) studied this question.

synapsesocial.com/papers/6a93f08e6c1a8fb52e79cc77 https://doi.org/10.1007/s11033-026-12623-y

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August 30, 2026Molecular Biology ReportsOpen Access

The regulatory role of post-translational modifications in the pathogenesis of ulcerative colitis

View Full Paper

Ask AI

Bookmark

Authors

YJYuan JiJiangxi Provincial Cancer Hospital BWBajin WeiFirst Affiliated Hospital Zhejiang University

Discussion

Member takes

Implication

Review uncovers the regulatory roles of post-translational modifications in ulcerative colitis, highlighting novel therapeutic targets for gut mucosal inflammation.

Key Points

Summarize the regulatory mechanisms and biological roles of protein post-translational modifications in the pathogenesis of ulcerative colitis.
Conducted a comprehensive review evaluating the role of protein post-translational modifications in ulcerative colitis etiology.
Synthesized evidence across multiple modification pathways, including phosphorylation, glycosylation, acetylation, methylation, ubiquitination, citrullination, and palmitoylation.
Post-translational modifications critically govern protein activity, structural stability, intracellular signaling networks, and intestinal cellular homeostasis.
Dysregulated modifications impair colonic epithelial barrier integrity and trigger aberrant immune and inflammatory signaling pathways.
Elucidating aberrant post-translational modification networks identifies promising candidate targets for future ulcerative colitis therapeutics.

Cite This Study

Ji et al. (2026) studied this question.

synapsesocial.com/papers/6a93f08e6c1a8fb52e79cc77 https://doi.org/10.1007/s11033-026-12623-y

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