What does this research mean for the field?

Patients with primary bone sarcoma in low-resource settings experience substantial delays throughout the diagnostic and treatment pathway, primarily driven by patient delay, with older age and farming occupation independently associated with prolonged time to treatment initiation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate diagnostic and treatment delay intervals and identify independent factors linked to prolonged time to treatment initiation in patients with primary bone sarcoma.

August 30, 2026BMC Research NotesOpen Access

Delays in diagnosis and treatment of primary bone sarcoma: a retrospective cohort study

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To evaluate diagnostic and treatment delay intervals and identify independent factors linked to prolonged time to treatment initiation in patients with primary bone sarcoma.
Retrospective cohort study analyzing 212 patients with histologically confirmed primary bone sarcoma managed at a tertiary referral center in Ethiopia between January 2021 and January 2025.
Assessed patient delay, diagnostic delay, and time to treatment initiation (TTI), employing multivariable gamma regression to identify factors independently associated with TTI.
The median total symptom interval was 161 days (IQR: 126–220), driven primarily by patient delay at 3 months (IQR: 2–5), diagnostic delay of 35 days (IQR: 26–45), and TTI of 23 days (IQR: 18–27), with 67.5% presenting at Enneking stage IIB.
Multivariable gamma regression identified age older than 40 years (expected 22% longer TTI) and farming occupation (expected 9% longer TTI) as independent predictors of extended TTI, whereas lower extremity tumor location correlated with an expected 7% shorter TTI.

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Implication

Cohort study reveals substantial diagnostic and treatment delays in bone sarcoma patients, highlighting the need for earlier detection and accessible oncologic care.

Cite This Study

Zeleke et al. (2026) studied this question.

synapsesocial.com/papers/6a93f0e06c1a8fb52e79d57d https://doi.org/10.1186/s13104-026-07992-3

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Implication

Cohort study reveals substantial diagnostic and treatment delays in bone sarcoma patients, highlighting the need for earlier detection and accessible oncologic care.

Delays in diagnosis and treatment of primary bone sarcoma: a retrospective cohort study

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Discussion

Implication

Cite This Study

Delays in diagnosis and treatment of primary bone sarcoma: a retrospective cohort study

Key Points

Discussion

Implication

Cite This Study

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