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Experimental study demonstrates improved reaction kinetics and energy efficiency for synthesizing benzoxazolone Schiff bases using ultrasound, highlighting greener routes to antibacterial agents.
Benzoxazolone derivatives (BOA) have attracted considerable attention due to their diverse pharmacological potential as therapeutic agents. In this work, we describe an eco-friendly ultrasonic-assisted synthesis method, as well as a conventional method, for the preparation of novel BOA derivatives (1–4). Furthermore, the BOA derivatives were reacted with p-nitro-, p-chloro-, and p-hydroxyanilines to produce Schiff bases (5–8). The results showed that, compared with conventional approaches, the ultrasonic-assisted method exhibits improved reaction kinetics and energy efficiency.
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Klimko et al. (2026) studied this question.
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