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August 30, 2026International Journal of Environmental Health Research

Curcumin and nanocurcumin attenuate ethanol-induced cognitive and oxidative impairments in male rats

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Authors

MGMohammad Javad GhobadiFVFarhad ValizadeganAMAkbar Hajizadeh Moghaddam

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Overview

Animal study demonstrates that curcumin and nanocurcumin reverse memory deficits and oxidative stress in ethanol-treated rats, highlighting nanocurcumin as a neuroprotective agent.

Key Points

  • To assess whether curcumin and its nanoformulation (nanocurcumin) protect against ethanol-induced cognitive decline and hippocampal oxidative imbalance in male rats.
  • Assigned 42 male rats to six groups (n = 7 per group): saline control, ethanol (20% intraperitoneal injection), and four co-treatment groups receiving oral curcumin or nanocurcumin at 100 or 200 mg/kg daily for 15 days.
  • Evaluated recognition memory using the novel object recognition test (NORT) and anxiety-like behavior via the elevated plus maze test (EPMT).
  • Quantified hippocampal antioxidant biomarkers, including catalase (CAT), superoxide dismutase (SOD), and reduced glutathione (GSH).
  • Ethanol administration significantly impaired memory by reducing the discrimination index on the NORT compared to controls (p < 0.001), whereas curcumin and nanocurcumin at both 100 and 200 mg/kg significantly reversed this decline (p < 0.001).
  • Ethanol exposure significantly decreased hippocampal antioxidant defenses, lowering CAT (p < 0.01), SOD (p < 0.001), and GSH (p < 0.001) relative to control levels.
  • Both treatments restored hippocampal antioxidant enzyme levels, with nanocurcumin demonstrating superior efficacy over standard curcumin, particularly at the 200 mg/kg dose.

Cite This Study

Ghobadi et al. (2026) studied this question.

synapsesocial.com/papers/6a93f0f56c1a8fb52e79d8c6https://doi.org/10.1080/09603123.2026.2725122
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