What question did this study set out to answer?

To describe the therapeutic impact of plasma exchange in a patient with treatment-resistant anti-MDA5-positive dermatomyositis complicated by rapidly progressive interstitial lung disease.

August 30, 2026Türk anesteziyoloji ve reanimasyon derneği dergisiOpen Access

Successful Therapeutic Plasma Exchange in Refractory Anti-MDA5-Positive Dermatomyositis and Rapidly Progressive-Interstitial Lung Disease: A Case Report

Q: What does this research mean for the field?

Therapeutic plasma exchange (TPE) can be an effective, life-saving intervention for patients with anti-MDA5-positive clinically amyopathic dermatomyositis (CADM) and rapidly progressive-interstitial lung disease (RP-ILD) who are refractory to traditional immunosuppressive treatments. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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To describe the therapeutic impact of plasma exchange in a patient with treatment-resistant anti-MDA5-positive dermatomyositis complicated by rapidly progressive interstitial lung disease.
Evaluated a 60-year-old female with anti-MDA5-positive clinically amyopathic dermatomyositis and rapidly progressive interstitial lung disease refractory to pulse steroids, tacrolimus, and intravenous immunoglobulin (N=1).
Administered four sessions of therapeutic plasma exchange on alternate days alongside continuous clinical and laboratory monitoring.
Achieved marked clinical and laboratory improvements following four alternate-day sessions of therapeutic plasma exchange.
Halted progressive respiratory deterioration and resolved elevated inflammatory markers after failure of conventional multi-agent immunosuppressive therapy.

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Implication

Case report demonstrates clinical recovery following therapeutic plasma exchange in refractory anti-MDA5-positive dermatomyositis, indicating its rescue potential.

Cite This Study

Balkan et al. (2026) studied this question.

synapsesocial.com/papers/6a93f1176c1a8fb52e79db9d https://doi.org/10.4274/tjar.2026.252250

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Implication

Case report demonstrates clinical recovery following therapeutic plasma exchange in refractory anti-MDA5-positive dermatomyositis, indicating its rescue potential.

Successful Therapeutic Plasma Exchange in Refractory Anti-MDA5-Positive Dermatomyositis and Rapidly Progressive-Interstitial Lung Disease: A Case Report

Key Points

Discussion

Implication

Cite This Study

Successful Therapeutic Plasma Exchange in Refractory Anti-MDA5-Positive Dermatomyositis and Rapidly Progressive-Interstitial Lung Disease: A Case Report

Key Points

Discussion

Implication

Cite This Study

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