Experimental study demonstrates stable hemodynamics, thermal control, and low priming volume in rats, highlighting a viable platform for testing circulatory support technologies.
BACKGROUND: Extracorporeal circulation (ECC) has become an important component in cardiac surgery, for cardiopulmonary support, and as a bridge to transplantation. Optimization of systems, components, and management requires further refinements using relevant ECC models. METHODS: and a pump-head tube with internal dimension, ID 2.0 mm, was connected to the rat with a double-lumen tube, where the inner silicone tube (ID 1.0 mm) was irrigated with temperature-controlled water, serving as a heat-exchanger. RESULTS: The ECC system had a priming volume less than 1.5 mL yet developed a pulsatile flow up to 11.6 mL/min, or 40 mL/min/kg, for a 290-g animal. The system kept sufficient gas exchange, sustained stable hemodynamics in heart failure, and induced hyperthermia (40°C) and hypothermia (20°C) successfully with long-term survival. CONCLUSION: A silicone-based closed ECC system for rodents was developed as an experimental platform to address controversies, optimize management, and test the feasibility of new systems, components, or concepts in ECC.
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Kawaguchi et al. (2026) studied this question.
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