What does this research mean for the field?

THBS1 promotes gastric cancer peritoneal metastasis by targeting tumor-associated macrophages and inducing metabolic reprogramming. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the functional role and metabolic mechanisms of thrombospondin 1 (THBS1) in driving gastric cancer peritoneal metastasis via communication with tumor-associated macrophages.

August 30, 2026Comprehensive physiology

THBS1 Targets Tumor‐Associated Macrophages to Regulate Gastric Cancer Peritoneal Metastasis via Metabolic Reprogramming

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To investigate the functional role and metabolic mechanisms of thrombospondin 1 (THBS1) in driving gastric cancer peritoneal metastasis via communication with tumor-associated macrophages.
Characterized interactions between gastric cancer cells and M2 macrophages using bulk, single-cell, and spatial transcriptomics, followed by RNA immunoprecipitation to detect THBS1 and SDC4 binding.
Assessed cancer cell proliferation, invasion, macrophage polarization, and metabolic parameters (ATP, mitochondrial membrane potential, and glucose/lipid metabolism genes) after THBS1 knockdown in a co-culture model.
Evaluated peritoneal metastatic burden in vivo using a BALB/c mouse model of gastric cancer peritoneal dissemination.
Transcriptomic screening identified THBS1, SEMA7A, and HBEGF as key intercellular mediators, with RNA immunoprecipitation confirming targeted binding between THBS1 and SDC4.
THBS1 knockdown suppressed cancer cell proliferation, migration, invasion, and M2 polarization, while decreasing mitochondrial membrane potential, ATP production, and expression of HIF-1ɑ, PFKFB3, ABHD5, and MGLL.
Targeted depletion of THBS1 markedly reduced peritoneal metastatic tumor burden in the mouse model.

Authors

ZSZheyu SongSun Yat-sen University YWYuanyu WuUnion Hospital

Discussion

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Implication

Preclinical study reveals THBS1 promotes gastric cancer peritoneal metastasis by reprogramming macrophage metabolism, highlighting a promising therapeutic target.

Cite This Study

Song et al. (2026) studied this question.

synapsesocial.com/papers/6a93f1626c1a8fb52e79e41b https://doi.org/10.1002/cph4.70244

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Implication

Preclinical study reveals THBS1 promotes gastric cancer peritoneal metastasis by reprogramming macrophage metabolism, highlighting a promising therapeutic target.

THBS1 Targets Tumor‐Associated Macrophages to Regulate Gastric Cancer Peritoneal Metastasis via Metabolic Reprogramming

Key Points

Discussion

Implication

Cite This Study

THBS1 Targets Tumor‐Associated Macrophages to Regulate Gastric Cancer Peritoneal Metastasis via Metabolic Reprogramming

Key Points

Discussion

Implication

Cite This Study

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