Association Between Blood Type Clinical Course and Sputum Microorganisms in Bronchiectasis

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In adult patients with non-cystic fibrosis bronchiectasis, ABO blood groups do not significantly affect exacerbation frequency, mortality, or sputum microbiology, although blood group B is associated with a higher rate of emergency admissions. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Güzide Tomas; Ayşe Çapar; Aslı Mezide Dulkadiroğlu; Şeyma Başlılar

doi:10.35514/mtd.2026.145

August 29, 2026Maltepe Tıp DergisiOpen Access

Association Between Blood Type Clinical Course and Sputum Microorganisms in Bronchiectasis

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Key Points

To evaluate the relationship between ABO blood groups, clinical course, and sputum microbiology in adult patients with non-cystic fibrosis bronchiectasis.
Retrospective review of hospital records and sputum cultures from N=102 adult bronchiectasis patients (51 males, 51 females) followed between January 2016 and October 2024.
Patients were stratified by ABO blood group (O, A, B, and AB) and compared for clinical outcomes—including exacerbation frequency, hospitalizations, intensive care unit admissions, emergency visits, and mortality—alongside sputum culture results.
Across the entire cohort, Pseudomonas aeruginosa was detected in 26 patients (with colonization in 6), intensive care unit admission was required in 25.5% (n=25/102), and overall mortality was 19.3% (n=19/102).
Most clinical and microbiological parameters—including exacerbation rates, mortality, lung function, and bacterial species—did not significantly differ across ABO blood groups.
Patients with blood group B had a significantly higher median number of annual emergency department visits for lower respiratory tract infections compared to other blood groups (p=0.047).

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Implication

Retrospective study finds higher emergency visits among blood group B in bronchiectasis patients, indicating mostly limited associations between ABO blood type and respiratory outcomes.

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Tomas et al. (2026) studied this question.

synapsesocial.com/papers/6a93f1736c1a8fb52e79e6e3 https://doi.org/10.35514/mtd.2026.145

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Association Between Blood Type Clinical Course and Sputum Microorganisms in Bronchiectasis

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Association Between Blood Type Clinical Course and Sputum Microorganisms in Bronchiectasis

Key Points

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Abstract

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