Key result
Sodium bisulphite treatment revealed that approximately 90% of cytosine residues in the poly(C) tract of encephalomyocarditis virus RNA are not base-paired, indicating it is largely single-stranded.
Population
Encephalomyocarditis virus (EMCV) RNA
Comparison
Sodium bisulphite treatment vs Synthetic polynucleotide lacking secondary…
Design
Preclinical
Authors
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Supports EMCV RNA structure models in myocarditis research; leaves open functional and therapeutic implications pending validation.
Absolute Event Rate: 74% vs 18%
The poly(C) tract of encephalomyocarditis virus RNA in solution is very largely single-stranded.
Goodchild et al. (1975) studied Encephalomyocarditis virus (EMCV) RNA secondary structure. Sodium bisulphite vs. Poly(I) annealed RNA was evaluated on Percentage conversion of C to U in the poly(C) tract. Sodium bisulphite treatment revealed that approximately 90% of cytosine residues in the poly(C) tract of encephalomyocarditis virus RNA are not base-paired, indicating it is largely single-stranded.
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