Key result
Induction of one-kidney, one wrapped hypertension in dogs increased saphenous vein water and sodium in benign cases, but decreased sodium in malignant cases.
Why the study?
Does the induction of benign versus malignant hypertension alter the water and sodium content of the saphenous vein in dogs?
Population
26 dogs with one-kidney, one wrapped hypertension
Comparison
Induction of hypertension vs Baseline measurements from the contralateral…
Design
Preclinical
Authors
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Differential vascular sodium content by hypertension severity in dogs should not change practice; leaves open human translational relevance.
Does the induction of benign versus malignant hypertension alter the water and sodium content of the saphenous vein in dogs?
The sodium content of blood vessels may predict the response to a hypertension-producing stimulus, with malignant hypertension associated with a fall in vascular sodium content compared to an increase in benign hypertension.
Simon et al. (1984) studied Renal Hypertension (n=26). One-kidney, one wrapped hypertension vs. Contralateral saphenous vein prior to induction was evaluated on Water and sodium content of the saphenous vein. Induction of one-kidney, one wrapped hypertension in dogs increased saphenous vein water and sodium in benign cases, but decreased sodium in malignant cases.
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