What is the clinical evidence from this study?

Study design: Other. Population: Suspected ischemic heart disease with sympathetic excitement (n=20). Intervention: Aspirin vs. Ticlopidine. Primary outcome: Platelet aggregation induced by 1 µg/ml collagen at 45 minutes (p=<0.05).

January 1, 2003Circulation JournalOpen Access

Timing of Anti-Platelet Effect After Oral Aspirin Admin-istration in Patients With Sympathetic Excitement

Q: What are the key findings of this study?

In patients with sympathetic excitement undergoing coronary angiography, oral aspirin significantly inhibited platelet aggregation starting at 45 minutes, whereas ticlopidine showed no effect by 120 minutes.

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Key result

In patients with sympathetic excitement undergoing coronary angiography, oral aspirin significantly inhibited platelet aggregation starting at 45 minutes, whereas ticlopidine showed no effect by 120 minutes.

Why the study?

Does oral aspirin or ticlopidine provide rapid antiplatelet effects in patients with sympathetic excitement undergoing coronary angiography?

Population

20 male patients suspected of having ischemic heart disease undergoing coronary angiogram for the first time.

Design

Cohort

Follow-up

120 minutes

Authors

ANAtsushi NishiyamaTokyo Dental College ONOsamu NiikawaNagasaki University HMHiroshi MohriAaron Diamond AIDS Research Center

Discussion

Member takes

Implication

Supports delayed aspirin effect in sympathetic excitement; leaves open optimal pre-PCI antiplatelet timing.

Structured PICO

Does oral aspirin or ticlopidine provide rapid antiplatelet effects in patients with sympathetic excitement undergoing coronary angiography?

Population

20 male patients aged 50-82 years suspected of ischemic heart disease undergoing their first coronary angiogram, evaluated for up to 120 minutes after drug administration.

Intervention

Aspirin 162 mg oral (n=10) or Ticlopidine 100 mg oral (n=10) administered immediately prior to coronary angiogram.

Outcome

Timing of antiplatelet effect (platelet aggregation induced by collagen or ADP) and plasma aspirin concentration up to 120 minutes.surrogate

Main Result

p-value: p=<0.05

In patients with sympathetic excitement, oral aspirin absorption is delayed, suggesting it should be administered at least 45 minutes before the first balloon dilatation during PCI.

Limitations

Patients did not have chest symptoms on examination, unlike actual AMI patients who have severe chest pains and may vomit.
The test was performed with fasting patients, whereas the timing and amount of food ingested may affect drug absorption.
Patients did not have chest symptoms (unlike actual AMI patients who have severe pain and may vomit)
The test was performed with fasting patients, whereas timing and amount of prior food ingestion may affect drug absorption

Cite This Study

Nishiyama et al. (2003) studied Suspected ischemic heart disease with sympathetic excitement (n=20). Aspirin vs. Ticlopidine was evaluated on Platelet aggregation induced by 1 µg/ml collagen at 45 minutes (p=<0.05). In patients with sympathetic excitement undergoing coronary angiography, oral aspirin significantly inhibited platelet aggregation starting at 45 minutes, whereas ticlopidine showed no effect by 120 minutes.

synapsesocial.com/papers/6a93f292ca2e050a7b8fa009 https://doi.org/10.1253/circj.67.697

Topics

Dual antiplatelet therapy

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Timing of Anti-Platelet Effect After Oral Aspirin Admin-istration in Patients With Sympathetic Excitement

Discussion

Member takes

Implication

Structured PICO

Main Result

Limitations

Cite This Study

Topics

Timing of Anti-Platelet Effect After Oral Aspirin Admin-istration in Patients With Sympathetic Excitement

Discussion

Member takes

Implication

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Topics

Also Consider