Nonsedating antihistamines are recommended as first-line treatment for patients with urticaria. The current European Academy of Allergology and Clinical Immunology/Global Allergy and Asthma European Network/European Dermatology Forum (EAACI/GA 2 LEN/EDF) guidelines call for updosing of nonsedating antihistamines (up to four times the standard dose) in those urticaria patients who do not respond satisfactorily to the standard doses. [1] There are a few studies to assess the efficacy of such a recommendation.
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KiranV Godse (2011) studied this question.
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