A monoclonal antibody against the platelet glycoprotein IIb/IIIa receptor complex prevents platelet aggregation and thrombosis in a canine model of coronary angioplasty.
Key result
In a canine model of coronary angioplasty, the 7E3 antiplatelet antibody was superior to aspirin in inhibiting platelet aggregation, thrombosis, and acute closure after deep arterial injury.
Why the study?
Does 7E3 F(ab')2 prevent platelet aggregation and thrombosis compared to aspirin or placebo in a canine model of coronary angioplasty?
Population
24 open-chest dogs in a canine coronary balloon angioplasty model
Comparison
0.8 mg/kg 7E3 F2 vs Saline placebo (n=8) or 325 mg aspirin (n=8)
Design
Preclinical
Follow-up
2 hours
Authors
Discussion
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Implication
Supports preclinical rationale for GP IIb/IIIa inhibition beyond aspirin; leaves open translation to human angioplasty outcomes.
Structured PICO
Does 7E3 F(ab')2 prevent platelet aggregation and thrombosis compared to aspirin or placebo in a canine model of coronary angioplasty?
P
Population
24 dogs undergoing coronary balloon angioplasty in an experimental model to evaluate antiplatelet therapies.
I
Intervention
0.8 mg/kg 7E3 F(ab')2 (monoclonal antibody against platelet glycoprotein IIb/IIIa receptor)
C
Comparator
Saline placebo (n=8) or 325 mg aspirin (n=8)
O
Outcome
Ex vivo platelet aggregation and in vivo thrombosis (hyperemic coronary blood flow and thrombus visualization) over 2 hourssurrogate
In a canine model of coronary angioplasty, the 7E3 antiplatelet antibody was superior to aspirin in preventing platelet aggregation and thrombosis.
Cite This Study
Bates et al. (1991) studied Coronary angioplasty and thrombosis (n=24). 7E3 F(ab')2 monoclonal antibody vs. Saline placebo and 325 mg aspirin was evaluated on Platelet aggregation, hyperemic coronary blood flow, and thrombosis. In a canine model of coronary angioplasty, the 7E3 antiplatelet antibody was superior to aspirin in inhibiting platelet aggregation, thrombosis, and acute closure after deep arterial injury.