Comparison of the Thermal Stabilities and Solubilities of Human Hypertrophic Scar, Normal Scar and Normal Skin Collagens

The thermal stability and solubility profiles of human hypertrophic scar collagen have been measured and compared with those of the collagens present in human normal scar, human normal skin and a lathyritic dermal tissue. The thermal stability profiles of the hypertrophic scar collagens were found to be very similar to each other and to closely resemble that of lathyritic collagen but differ significantly from those obtained with the other dermal collagens. The hydrothermal solubility profiles did not, however, show a clear distinction between normal and hypertrophic scars.