Use of Di-Isopropyl Fluorophosphate (Dfp) in Treatment of Glaucoma

THE RECENT report of Leopold and McDonald1on the use of di-isopropyl fluorophosphate (D F P) in the treatment of glaucoma covers a series of 370 eyes for an observation period of thirty-seven months. In this paper reference is made to previously published data on the application of this drug in clinical ophthalmology. Our series at the Institute of Ophthalmology of the Columbia University-Presbyterian Medical Center is much smaller, and the observation period is in many instances shorter. It is felt that the results obtained may prove informative in the evaluation of earlier work. METHOD In a two year period, 150 glaucomatous eyes, in 121 patients, which did not respond to other miotics or to operation were treated with di-isopropyl fluorophosphate. A 0.2 per cent solution of di-isopropyl fluorophosphate in peanut oil was used, and the response of the eye to the first instillation determined the frequency of instillation