Current Understanding of the Relationship of HDL Composition, Structure and Function to Their Cardioprotective Properties in Chronic Kidney Disease
Key result
This review summarizes the relationship of HDL composition, metabolism, and function to their cardioprotective properties in chronic kidney disease, focusing on changes in the HDL proteome.
Why the study?
In CKD, neither HDL cholesterol levels nor cholesterol efflux capacity associate with cardiovascular events, prompting investigation into whether HDL composition, metabolism, and functional subclasses explain their cardioprotective properties.
Design
Review
Authors
Discussion
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Implication
HDL efflux capacity does not predict CV events in CKD; leaves open whether HDL-targeted interventions could still modify risk in renal disease.
Structured PICO
P
Population
Patients with chronic kidney disease (CKD)
Investigating the functional and compositional features of HDL subclasses, rather than just HDL cholesterol levels, may be necessary to understand the link between HDL and cardiovascular disease in patients with chronic kidney disease.
Cite This Study
Marsche et al. (2020) conducted a review in Chronic kidney disease. HDL composition, structure and function was evaluated. This review summarizes the relationship of HDL composition, metabolism, and function to their cardioprotective properties in chronic kidney disease, focusing on changes in the HDL proteome.