Key result
Protease-sensitive enteroviruses like coxsackievirus type A9 are inactivated primarily by degradation of the virus capsid by proteolytic enzymes, with subsequent release of viral RNA.
Population
Coxsackievirus type A9 (CA9) labeled with (14)C-leucine or (32)P
Comparison
Proteolytic enzymes vs Untreated CA9 or CA9 reacted with ribonuclease
Design
Preclinical
Authors
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May inform enteroviral myocarditis mechanisms; leaves open translation to human cardiac infection.
Proteolytic enzymes inactivate Coxsackievirus Type A9 by degrading the viral capsid and releasing viral RNA.
Herrmann et al. (1973) studied Coxsackievirus type A9 (CA9). Proteolytic enzymes (Pronase, trypsin, Pseudomonas aeruginosa filtrates) vs. Untreated CA9 or CA9 reacted with ribonuclease was evaluated on Viral capsid degradation and viral RNA release. Protease-sensitive enteroviruses like coxsackievirus type A9 are inactivated primarily by degradation of the virus capsid by proteolytic enzymes, with subsequent release of viral RNA.
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