Factors Influencing the Enhancement of the Infectivity of Poliovirus Ribonucleic Acid by Diethylaminoethyl-Dextran
Population
Nonprimate (L) and primate cell systems (MK, HeLa, LLC-MK(2))
Design
Preclinical
Authors
Discussion
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Implication
May aid in vitro nucleic acid delivery studies; leaves open clinical translation or therapeutic use.
Structured PICO
P
Population
Nonprimate (L) and primate cell systems (MK, HeLa, LLC-MK(2))
I
Intervention
Diethylaminoethyl-dextran (DEAE-D)
O
Outcome
Enhancement of infectivity of poliovirus ribonucleic acid (RNA)
DEAE-D enhances the infectivity of poliovirus RNA in cell cultures by reducing ribonuclease activity and increasing cell susceptibility.
Cite This Study
Pagano et al. (1967) studied this question.