November 1, 1962Journal of BacteriologyOpen Access

Enhancement of the Plaque-Forming Capacity of Poliovirus Ribonucleic Acid With Basic Proteins

View Full Paper

Ask AI

Bookmark

Population

HeLa cells and poliovirus ribonucleic acid (RNA) preparations

Comparison

Addition of basic proteins vs Poliovirus RNA without basic proteins or with…

Design

Preclinical

Authors

Discussion

May enhance viral RNA uptake in vitro; leaves open relevance to in vivo infection or RNA therapeutics.

Population

HeLa cells and poliovirus ribonucleic acid (RNA) preparations

Intervention

Addition of basic proteins (histone at 200 to 400 mug per ml or protamine at approximately 600 mug per ml)

Comparator

Poliovirus RNA without basic proteins or with other basic materials/proteins

Outcome

Infectivity of the RNA for HeLa cells (plaque-forming capacity)

Basic proteins such as histone and protamine significantly enhance the infectivity of poliovirus RNA in HeLa cells.

Smull et al. (1962) studied this question.

View Full Paper

Ask AI

Bookmark