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November 1, 1957The Journal of Experimental MedicineOpen Access

Growth Characteristics of Poliovirus in Hela Cells: Nucleic Acid Metabolism

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Population

HeLa cells

Comparison

Infection with poliovirus vs Ordinary HeLa cells maintained under standard…

Design

Preclinical

Follow-up

Up to 7 hours after infection

Authors

HMH. F. MaassabUniversity of MichiganPLPhilip C. LohUniversity of Hawaiʻi at MānoaWAW. W. AckermannDarmstadt University of Applied Sciences

Discussion

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Implication

Early cytoplasmic RNA synthesis precedes poliovirus; extends in vitro replication models but leaves open in vivo and therapeutic relevance.

Structured PICO

P
Population
HeLa cells
I
Intervention
Infection with poliovirus
C
Comparator
Ordinary HeLa cells maintained under standard conditions (uninfected)
O
Outcome
Changes in the rates of incorporation of P(32) and in the amounts of RNA and DNAsurrogate

Poliovirus infection in HeLa cells induces a net synthesis of cytoplasmic RNA that precedes the appearance of newly formed virus.

Cite This Study

Maassab et al. (1957) studied this question.

synapsesocial.com/papers/6a8326ce992e36291ff46167https://doi.org/10.1084/jem.106.5.641
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1STUDIES ON THE PROPAGATION IN VITRO OF POLIOMYELITIS VIRUSES1953 · 869 citations
  2. 2THE INTRACELLULAR LOCALIZATION OF POLIOMYELITIS VIRUS1953 · 20 citations
  3. 3Cytopathogenic Effect of Poliomyelitis Viruses In vitro on Human Embryonic Tissues.1950 · 81 citations
  4. 4Studies on the Cultivation of Poliomyelitis Viruses in Tissue Culture1952 · 50 citations
  5. 5GROWTH CHARACTERISTICS OF POLIOMYELITIS VIRUS IN HELA CELL CULTURES: LACK OF PARALLELISM IN CELLULAR INJURY AND VIRUS INCREASE1954 · 83 citations