September 1, 1973Journal of Cell Science

Factors determining the site of synthesis of poliovirus proteins: The early attachment of virus particles to endoplasmic membranes

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Population

HeLa cells infected with radioactive poliovirus

Design

Preclinical

Follow-up

1 to 2 hours

Authors

MFM. L. FenwickUConn Health MWM. J. WallUniversity of Toronto

Discussion

Member takes

Implication

Poliovirus-ER attachment may mark early infection; leaves open its role in directing viral protein synthesis.

Structured PICO

Population

HeLa cells infected with radioactive poliovirus

Intervention

Infection with radioactive poliovirus

Outcome

Association of virus particles with endoplasmic reticulum/membranessurrogate

Attachment of poliovirus particles to the endoplasmic reticulum may be an early stage in the infectious cycle that determines the site of subsequent viral protein synthesis.

Cite This Study

Fenwick et al. (1973) studied this question.

synapsesocial.com/papers/6a85a22abeaf5c5b091091e9 https://doi.org/10.1242/jcs.13.2.403

View Full Paper

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Factors determining the site of synthesis of poliovirus proteins: The early attachment of virus particles to endoplasmic membranes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Factors determining the site of synthesis of poliovirus proteins: The early attachment of virus particles to endoplasmic membranes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider