Key result
14S subunits act as the key intermediates in the encapsidation of poliovirus RNA by assembling with endogenous subunits and interacting with newly synthesized RNA to form virions.
14S subunits are identified as key intermediates in the encapsidation of poliovirus RNA in a cell-free system.
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Hypothesis-generating for poliovirus antivirals; leaves open in vivo translation and clinical relevance.
In a cell-free system of uninfected HeLa cells, programmed with poliovirus RNA, extraneous radiolabelled 14S subunits assembled with endogenous 14S subunits and interacted with newly synthesized RNA to form virions (160S). This result suggests that 14S subunits are the key intermediates in the encapsidation of poliovirus RNA.
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Verlinden et al. (2000) studied this question. 14S subunits act as the key intermediates in the encapsidation of poliovirus RNA by assembling with endogenous subunits and interacting with newly synthesized RNA to form virions.
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