Population
Human amnion cell line cultured on coverslips, with cytoplasmic fragments produced by micromanipulation
Design
Preclinical
Follow-up
7 hours
Authors
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Poliovirus replicates in enucleated mammalian cytoplasm; leaves open in vivo relevance and nuclear roles in intact cells.
Poliovirus infection and growth can occur in non-nucleate cytoplasm of mammalian cells, independent of the nucleus.
Crocker et al. (1964) studied this question.
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