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Different strains of Lactobacillus helveticus were tested for lysozyme resistance, and one out of three (L. helveticus CNRZ 892) showed a concomitant resistance to homologous phage 832-B1 (lysozyme-resistant, ~832-B I-resistant). The mechanism of phage resistance acquisition seemed to be related to a decreased phage adsorption as well as to a sharp decrease in plaque-forming ability (less than 1(}-8). Some lysozymeresistant and ~832-Bl-resistant derivatives of strain CNRZ 892 lost the ability to ferment galactose and trehalose and showed loss and rearrangement of plasmids.
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Neviani et al. (1992) studied this question.
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