Double-blind cross-over comparison of aceclidine and pilocarpine in open-angle glaucoma.

Aceclidine hydrochloride (3-acetoxyquinuclidine, "Glaucostat": Chibret) used topically in a strength of 2 per cent. is a parasympathomimetic drug acting directly on the motor end-plate (cholinergic nerve-endings). It is suitable for administration as eye drops, penetrating rapidly into the anterior chamber. It is a synthetic substance and was first prepared in Russia by Rubitzov and Miklina (i 960). The name "Aceclidine" was coined by Mashkovski and Zaitzeva (i960), who studied its pharmacological aspects. It was also described by Sharts and Shulpina (I96I).