Key result
Genetic variability in candidate genes is associated with outcomes in organ transplantation, providing a rationale for large prospective studies to define the benefits of genotyping.
Why the study?
Does genotyping for genetic polymorphisms predict transplant outcomes in renal transplant recipients?
Does genotyping for genetic polymorphisms predict transplant outcomes in renal transplant recipients?
Genetic variability plays a potential role in transplantation outcomes, highlighting the need for prospective studies to define the benefits of genotyping for risk stratification.
PURPOSE OF REVIEW: The purpose of this review is to summarize recent advances within the area of genetic polymorphisms with a specific emphasis on renal transplantation, and to discuss the potential clinical applications. RECENT FINDINGS: Due to recent advances in molecular techniques, there has been an abundance of publications describing genetic variability in molecules relevant to transplant outcome. Many studies are now demonstrating associations between polymorphisms in these candidate genes and outcomes in organ transplantation. SUMMARY: These studies emphasize the potential role of genetic variability in transplantation, and provide the rationale for large prospective studies to clearly define the potential benefits of genotyping in the risk stratification of transplant recipients.
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Marder et al. (2003) conducted a review in Renal transplantation. Genetic polymorphisms was evaluated on Transplant outcome. Genetic variability in candidate genes is associated with outcomes in organ transplantation, providing a rationale for large prospective studies to define the benefits of genotyping.
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