Population
Isolated perfused hearts and isolated cardiac trabeculas
Comparison
Coronary venous effluent and endothelial cell… vs Standard Krebs' solution
Design
Preclinical
Key result
Endothelin released by coronary vascular endothelial cells accounts for the upregulation of cardiac contractility, an effect that is inhibited by the endothelin antagonist BQ123.
Authors
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Endothelin pathway modulation merits exploration in human models; leaves open any therapeutic role for BQ123 in contractile dysfunction.
Endothelin released by coronary vascular endothelial cells acts as a key cardioregulatory mechanism, upregulating cardiac contractility in response to coronary flow and tissue oxygen tension.
McClellan et al. (1994) studied this question. Endothelin and endothelin antagonist BQ123 was evaluated on Contractility of isolated cardiac trabeculas. Endothelin released by coronary vascular endothelial cells accounts for the upregulation of cardiac contractility, an effect that is inhibited by the endothelin antagonist BQ123.
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