Key result
Elevated pre-operative IL-6 levels independently predicted severe post-operative complications in older patients undergoing colorectal cancer surgery (OR 2.4; 95% CI 1.14-5.06).
Why the study?
Do pre-operative inflammatory biomarkers predict post-operative complications in older frail and non-frail patients undergoing colorectal cancer surgery?
Cohort (n=137)
Yes
Do pre-operative inflammatory biomarkers predict post-operative complications in older frail and non-frail patients undergoing colorectal cancer surgery?
Odds Ratio: 2.4 (95% CI 1.14–5.06)
Pre-operative IL-6 levels independently predict severe post-operative complications in older patients undergoing colorectal cancer surgery, suggesting biomarkers may add validity to clinical frailty assessments.
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Pre-operative IL-6 may refine risk stratification in older colorectal cancer surgery patients; hypothesis-generating for biomarker integration with frailty tools.
Rønning et al. (2010) conducted a cohort in Colorectal cancer (n=137). Elevated IL-6 levels (>66.66th percentile) vs. IL-6 levels ≤66.66th percentile was evaluated on Severe post-operative complications (≥grade II) (OR 2.4, 95% CI 1.14-5.06). Elevated pre-operative IL-6 levels independently predicted severe post-operative complications in older patients undergoing colorectal cancer surgery (OR 2.4; 95% CI 1.14-5.06).
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