Synthesis, Spectroscopic Characterization, and in Vitro Antitumor Activity of Tetraphenylantimony Derivatives of Analogues of Demethylcantharidin and Demethyldehydrogen-Cantharidin

A series of novel tetraphenylantimony(V) derivatives of the analogues of demethylcantharidin and demethyldehydrogencantharidin, exo-7-oxa-bicyclo[2,2,1]-heptane-3-arylamide-2-carboxylic acid and exo-7-oxa-bicyclo[2,2,1]-heptene-3-arylamide-2-carboxylic acid, of the general formulas , , , and have been synthesized and characterized by elemental analyses, IR, 1H NMR and mass spectroscopy. Preliminary antitumor activity tests show that these compounds have significant antitumor activity in vitro against five human neoplastic cell lines.