Preclinical study demonstrates reduced autoimmunity in lupus mice via agonist antibody-driven M2 macrophage polarization, indicating a novel therapeutic pathway.
We have devised a method of using intracellular combinatorial libraries to select antibodies that control cell fates. Many agonist antibodies have been selected with this method, and the process appears to be limited only by the availability of a phenotypic selection system. We demonstrate the utility of this approach to discover agonist antibodies that engage an unanticipated target and regulate macrophage polarization by selective induction of anti‐inflammatory M2 macrophages. This antibody was used therapeutically to block autoimmunity in a classic mouse model of spontaneous systemic lupus erythematosus.—Han, K. H., Gonzalez‐Quintial, R., Peng, Y., Baccala R., Theofilopoulos, A. N., Lerner, R. A. An agonist antibody that blocks autoimmunity by inducing anti‐inflammatory macrophages. FASEB J. 30, 738‐747 (2016). www.fasebj.org
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Han et al. (2015) studied this question.
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