Key result
PTHrP(1-36) markedly potentiates catecholamine secretion to K+ depolarization in PC12 cells, depending entirely upon L-VSCC Ca2+ influx.
Population
PC12 clone expressing the PTH/PTHrP receptor but not PTHrP
Comparison
PTHrP(1-36) (100 nM) with K+ depolarization vs Resting cells, (Bu)2cAMP, carbachol
Design
Preclinical
Authors
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Premature for clinical translation; extends cellular mechanisms of adrenal regulation but leaves open in vivo relevance.
PTHrP potentiates depolarization-induced catecholamine release via L-type voltage-sensitive Ca2+ channels in PC12 cells, suggesting an autocrine/paracrine regulatory role in the adrenal medulla.
Brines et al. (1999) studied this question. PTHrP(1-36) vs. Resting cells was evaluated on Catecholamine secretion. PTHrP(1-36) markedly potentiates catecholamine secretion to K+ depolarization in PC12 cells, depending entirely upon L-VSCC Ca2+ influx.
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