Key result
Obesity is linked to ~19% lower resting stroke index vs. lean controls despite preserved stress reactivity.
Why the study?
Obesity is associated with hemodynamic and autonomic alterations, but the patterns of reactivity to mental and physical stress across lean, overweight, and obese subjects remain unclear.
Does obesity or being overweight alter resting hemodynamic and autonomic parameters or their reactivity to mental and physical stress in healthy adults?
Cross-Sectional (n=1,017)
No
Does obesity or being overweight alter resting hemodynamic and autonomic parameters or their reactivity to mental and physical stress in healthy adults?
Obesity and overweight status alter baseline autonomic and hemodynamic profiles but do not appear to augment physiological reactivity to acute mental or physical stress.
Obesity-linked resting hemodynamic shifts may warrant monitoring in normotensives; leaves open whether preserved stress reactivity influences long-term risk.
Obesity is a known risk for cardio-metabolic diseases such as hypertension, ischemic heart disease [1,2], type-2 diabetes mellitus [3] and comorbidities like obstructive sleep apnea [4].Previous studies showed hemodynamic and autonomic alterations in lean compared to obese [5,6] such as increased resting heart rate (HR), blood pressure (BP) [5,7], muscle sympathetic nerve activity (MSNA) [5,7,8], left ventricular mass index [9] and low frequency spectrum of heart rate variability (HRV) [6].Contrary to this, autonomic activity was also shown to decrease with obesity [10,11] and had inverse relationship with body fat percentage [1].
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Jaju et al. (2016) conducted a cross-sectional in Obesity (n=1,017). Obesity and Overweight vs. Lean (BMI 18.9-24.9 kg/m2) was evaluated on Resting stroke index (p=0.0001). Obesity and overweight were associated with altered resting hemodynamic parameters, such as a reduced stroke index in obese compared to lean subjects (40.1 vs 49.6 ml/m2, p=0.0001), but reactivity to acute mental and physical stress was similar across all groups.
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