Key result
Modern medicines and traditional Chinese medicines alleviate myocardial fibrosis by affecting related signaling pathways and inhibiting fibrosis-related protein synthesis.
Why the study?
Myocardial fibrosis is a common pathological feature of cardiovascular diseases, and both modern medicines and traditional Chinese medicines show therapeutic effects that warrant review.
This review highlights the potential of both modern medicines and traditional Chinese medicines in alleviating myocardial fibrosis, while noting the need for further mechanistic studies and standardization of TCM.
May support adjunctive use of β-blockers and TCM extracts in myocardial fibrosis; leaves open need for RCTs to guide practice.
Myocardial fibrosis, which is a common pathological manifestation of many cardiovascular diseases, is characterized by excessive proliferation, collagen deposition and abnormal distribution of extracellular matrix fibroblasts. In clinical practice, modern medicines, such as diuretic and β receptor blockers, and traditional Chinese medicines, such as salvia miltiorrhiza and safflower extract, have certain therapeutic effects on myocardial fibrosis. We reviewed some representative modern medicines and traditional Chinese medicines (TCMs) and their related molecular mechanisms for the treatment of myocardial fibrosis. These drugs alleviate myocardial fibrosis by affecting related signaling pathways and inhibiting myocardial fibrosis-related protein synthesis. This review will provide more references and help for the research and treatment of myocardial fibrosis.
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Ren et al. (2023) conducted a review in Myocardial fibrosis. Modern medicine and traditional Chinese medicine was evaluated. Modern medicines and traditional Chinese medicines alleviate myocardial fibrosis by affecting related signaling pathways and inhibiting fibrosis-related protein synthesis.
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