Key result
Nephrectomy of a renin-secreting renal cell carcinoma in a 14-year-old girl normalized her blood pressure and plasma renin levels.
Case Report (n=1)
A renin-secreting renal cell carcinoma can cause malignant hypertension, which is reversible upon surgical removal of the tumor.
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May prompt tumor evaluation in select pediatric malignant hypertension; extends curable secondary HTN etiologies but remains hypothesis-generating.
This is a case report of a 14-year-old girl who presented with malignant hypertension. She had high plasma levels of both active and inactive renin and investigation revealed a renal tumour. The tumour, a renal cell carcinoma, was removed by nephrectomy following which the blood pressure and the plasma renin levels fell to normal. An immunocytochemical study using an antibody to pure human renin showed no detectable renin in the kidney but the tumour contained a population of granular cells which showed strong positive staining for immunoreactive renin. We present the clinical, biochemical, histological, immunocytochemical and ultrastructural features of this case as evidence that this was a renin-secreting renal cell carcinoma.
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Lindop et al. (1986) conducted a case report in Malignant hypertension due to a renin-secreting renal cell carcinoma (n=1). Nephrectomy was evaluated on Blood pressure and plasma renin levels. Nephrectomy of a renin-secreting renal cell carcinoma in a 14-year-old girl normalized her blood pressure and plasma renin levels.
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