What question did this study set out to answer?

To review the pharmacological and physiological mechanisms distinguishing adaptive physiologic cardiac growth from maladaptive pathologic hypertrophy in the pressure-overloaded heart.

January 1, 1987Journal of Cardiovascular Pharmacology

Physiologic Versus Pathologic Hypertrophy and the Pressure-Overloaded Myocardium

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Key result

The provided text describes the scope of the Journal of Cardiovascular Pharmacology and contains no clinical study data.

Authors

KWKarl T. WeberHeart Failure / Cardiomyopathy WCWilliam A. ClarkPennsylvania State University JJJoseph S. JanickiHeart Failure & Transplant

Discussion

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Implication

No clinical data presented; leaves open need for primary evidence on cardiovascular pharmacotherapy.

Key Points

To review the pharmacological and physiological mechanisms distinguishing adaptive physiologic cardiac growth from maladaptive pathologic hypertrophy in the pressure-overloaded heart.
Literature review of basic and clinical cardiovascular pharmacology principles.
Evaluation of physiological mechanisms, drug development approaches, and therapeutic responses in myocardial pressure overload.
Differentiates the beneficial adaptations of physiologic cardiac remodeling from the destructive remodeling characteristic of sustained pressure-overload pathologic hypertrophy.
Identifies key physiological pathways and pharmacological interventions that modulate cardiac muscle enlargement, metabolism, and disease progression.

Cite This Study

Weber et al. (1987) studied this question. The provided text describes the scope of the Journal of Cardiovascular Pharmacology and contains no clinical study data.

synapsesocial.com/papers/6a9406798e5b8037ce43f3f4 https://doi.org/10.1097/00005344-198706106-00006

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Physiologic Versus Pathologic Hypertrophy and the Pressure-Overloaded Myocardium

Discussion

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Implication

Key Points

Cite This Study

Physiologic Versus Pathologic Hypertrophy and the Pressure-Overloaded Myocardium

Discussion

Member takes

Implication

Key Points

Cite This Study

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