Key result
Yin-Chen-Hao Tang significantly attenuated severe acute pancreatitis in rats by inducing apoptosis, repressing inflammation, alleviating oxidative stress, and regulating lipid metabolism.
Why the study?
Does Yin-Chen-Hao Tang (YCHT) attenuate severe acute pancreatitis in a rat model?
Does Yin-Chen-Hao Tang (YCHT) attenuate severe acute pancreatitis in a rat model?
Yin-Chen-Hao Tang attenuates severe acute pancreatitis in rats by inducing apoptosis, repressing inflammation, alleviating oxidative stress, and regulating lipid metabolism.
Answers are grounded in this paper and cite their sources.
Should not change clinical practice in pancreatitis; leaves open human translation of Yin-Chen-Hao Tang.
Yin-Chen-Hao Tang (YCHT) is a classical Chinese medicine compound that has a long history of clinical use in China for the treatment of inflammatory diseases. However, the efficacy and mechanisms of YCHT for the treatment of severe acute pancreatitis (SAP) are not known. The current study investigated the pharmacological properties of YCHT against SAP and its underlying mechanisms. A computational prediction of potential targets of YCHT was initially established based on a network pharmacology simulation. The model suggested that YCHT attenuated SAP progress by apoptosis inducement, anti-inflammation, anti-oxidation and blood lipid regulation. These effects were validated in SAP rats. YCHT administration produced the following results: (1) significantly inhibited the secretion of pancreatic enzymes and protected pancreatic tissue; (2) obviously increased the number of in situ terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL)-positive cells and induced apoptosis; (3) markedly inhibited neutrophil infiltration to the impaired pancreas and reduced the inflammatory reaction; (4) notably enhanced the activities of antioxidant enzymes and decreased the nitric oxide synthase (NOS) levels; (5) significantly reduced the levels of triglycerides (TG), total cholesterol (TC) and low-density lipoprotein (LDL) and increased high-density lipoprotein (HDL); and (6) significantly up-regulated peroxisome proliferator-activated receptor-γ (PPARγ) and down-regulated nuclear factor-kappa B (NF-κB). In summary, these results demonstrated that YCHT attenuated SAP progress by inducing apoptosis, repressing inflammation, alleviating oxidative stress and regulating lipid metabolism partially via regulation of the NF-κB/PPARγ signal pathway.
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Xiang et al. (2016) studied Severe acute pancreatitis (n=50). Yin-Chen-Hao Tang vs. Untreated SAP model and sham operation was evaluated on Plasma lactate dehydrogenase (LDH) level (U/L) (p=<0.01). Yin-Chen-Hao Tang significantly attenuated severe acute pancreatitis in rats by inducing apoptosis, repressing inflammation, alleviating oxidative stress, and regulating lipid metabolism.
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