Key result
The addition of a helium-oxygen mixture to standard therapy did not reduce mortality in adult patients with pneumonia.
Why the study?
The study was conducted to evaluate the effect of adding helium-oxygen mixture to standard therapy in adult patients with pneumonia.
Does the addition of a helium-oxygen mixture to standard therapy reduce mortality and improve clinical outcomes in adult patients with pneumonia?
Meta-Analysis (n=1,097)
Does the addition of a helium-oxygen mixture to standard therapy reduce mortality and improve clinical outcomes in adult patients with pneumonia?
The addition of a helium-oxygen mixture to standard therapy in adult pneumonia patients improves oxygenation and reduces hospitalization duration, but does not reduce mortality or the need for mechanical ventilation.
Answers are grounded in this paper and cite their sources.
HOM addition improves SpO2 recovery, shortens hospitalization, and lowers CRP/D-dimer in pneumonia; extends surrogate benefits without mortality or ventilation reduction.
OBJECTIVES. Evaluation of the effect addition helium-oxygen mixture (HOM) in adult patients with pneumonia compared with standard therapy. MATERIALS AND METHODS. Literature was searched in PubMed databases; Google Scholar and eLIBRARY.RU. The following factors were analyzed: the effect of HOM on mortality, SpO2 level, SpO2 recovery, C-reactive protein (CRP), ferritin, D-dimers, frequency of transfer to artificial lung ventilation, duration of stay in the intensive care unit (ICU), hospitalization, cough. Quality assessment, statistical data processing was performed in the Review Manager program, version 5.4.1. The reliability of evidence was evaluated using the GRADE approach using the GRADEpro GDT online program. RESULTS. The meta-analysis included 8 studies with a total of 1097 patients. In 4 out of 10 studied effects (mortality, ventilator rate, length of stay in the ICU, ferritin level), the results did not show the effect of adding HOM to standard therapy. A general meta-analysis of HOM effect showed an increase on SpO2 levels (MD: 1.68; 95% CI: 1.13–2.24; p < 0.001); the maximum effect was on 3–5 days and lasted up to 7 days. Positive effect HOM led to a faster recovery of SpO2 (MD: −2.91; 95% CI: −3.72 … −2.10; p < 0.001). Positive effect HOM led to reduction duration of hospitalization (MD: −3.40; 95% CI −6.05 … −0.76; p = 0.01), cough duration (MD: −3.00; 95% CI: −4.41 … −1.59; p < 0.001), CRP (MD: −16.83; 95% CI: −25.69 … −7.98; p = 0.0002), D-dimer (SMD: −0.48; 95% CI: −0.84 … −0.13; p = 0.007). CONCLUSIONS. The data obtained indicate that the addition of KGF to traditional therapy can improve oxygenation. The inclusion of HOM in therapy can reduce the duration of cough, as well as reduce the level CRP and D-dimers. There was no decrease in mortality, frequency of transfer to mechanical ventilation, duration of stay in the ICU.
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Лахин et al. (2022) conducted a meta-analysis in Pneumonia (n=1,097). Helium-oxygen mixture (HOM) vs. Standard therapy was evaluated on Mortality during hospital stay (OR 0.76, 95% CI 0.47-1.25, p=0.28). The addition of a helium-oxygen mixture to standard therapy did not reduce mortality in adult patients with pneumonia.
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