Key result
A single gene encoding both peroxisomal and mitochondrial carnitine acetyltransferases in Candida tropicalis was cloned, sequenced, and found to produce two distinct proteins via different mechanisms.
In Candida tropicalis, both peroxisomal and mitochondrial carnitine acetyltransferases are encoded by a single gene, with distinct translation initiation and signal cleavage mechanisms.
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No immediate clinical implications for cardiac metabolism; leaves open whether analogous single-gene mechanisms operate in mammals.
Kawachi et al. (1996) studied this question. Cloning and expression of carnitine acetyltransferase gene was evaluated on Gene sequence and protein expression. A single gene encoding both peroxisomal and mitochondrial carnitine acetyltransferases in Candida tropicalis was cloned, sequenced, and found to produce two distinct proteins via different mechanisms.
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