Posterior capsular opacification after extracapsular cataract extraction is usually caused by a proliferation of lens epithelial cells. This complication may be reduced by atraumatic surgery, thorough cortical cleanup, and use of specific intraocular lens designs. One-piece, biconvex-optic intraocular lenses implanted in the capsular bag seem to form a barrier against central migration of epithelial cells. Various pharmacologic and immunologic methods are being investigated, but long-term clinical data are not yet available.
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Solomon et al. (1992) studied this question.