What question did this study set out to answer?

To evaluate how genetic background influences splenic cytokine gene expression in chickens receiving diets supplemented with immunomodulatory compounds.

July 15, 2010Poultry ScienceOpen Access

Differential splenic cytokine responses to dietary immune modulation by diverse chicken lines

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Authors

SRSarah RedmondRadford University RTRenae TellCaptain James A. Lovell Federal Health Care Center DCDerrick CobleIowa State University

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Implication

Experimental study demonstrates line-dependent splenic cytokine responses to dietary immunomodulators in chickens, indicating that genetics shape nutritional immune modulation.

Key Points

To evaluate how genetic background influences splenic cytokine gene expression in chickens receiving diets supplemented with immunomodulatory compounds.
Chickens from an outbred broiler line and inbred Leghorn and Fayoumi lines were fed a basal diet or experimental diets containing beta-glucan, ascorbic acid, or corticosterone from day 56 to 77 of age.
Splenic mRNA expression of IL-4, IL-6, IL-18, MIP-1beta, IFN-gamma, and PI3K p110gamma was quantified via reverse transcription PCR to analyze effects of diet, genetic line, sex, and their interactions.
Corticosterone feeding significantly suppressed weight gain at 1, 2, and 3 weeks compared with all other diets (P < 0.001), and splenic IL-18 expression was higher in males than females (P = 0.010).
Significant line-by-diet interactions altered splenic expression of IL-4 (P = 0.021), IL-6 (P = 0.006), and IL-18 (P = 0.026), with broiler expression remaining unchanged, IL-4 and IL-18 shifting solely in Fayoumi birds, and IL-6 demonstrating opposing patterns between Fayoumi and Leghorn lines.

Cite This Study

Redmond et al. (2010) studied this question.

synapsesocial.com/papers/6a940bde65578a3bc5fec760 https://doi.org/10.3382/ps.2010-00846

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Implication

Experimental study demonstrates line-dependent splenic cytokine responses to dietary immunomodulators in chickens, indicating that genetics shape nutritional immune modulation.

Differential splenic cytokine responses to dietary immune modulation by diverse chicken lines

Discussion

Member takes

Implication

Key Points

Cite This Study

Differential splenic cytokine responses to dietary immune modulation by diverse chicken lines

Discussion

Member takes

Implication

Key Points

Cite This Study

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