Key result
Citrullination of proteins by PADI alters peptide antigenicity and is closely linked to the pathogenesis of rheumatoid arthritis autoimmunity.
Design
Review
Authors
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Warrants PADI inhibitor exploration in RA; leaves open clinical translation and cardiovascular relevance.
Highlights the mechanistic role of PADI-mediated protein citrullination in the development of rheumatoid arthritis autoimmunity.
Ryo Yamada (2005) conducted a review in Rheumatoid arthritis. Citrullinated proteins and PADI4 was evaluated. Citrullination of proteins by PADI alters peptide antigenicity and is closely linked to the pathogenesis of rheumatoid arthritis autoimmunity.
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