Research Progress in the Treatment of Heart Failure after Myocardial Infarction Using Traditional Chinese Medicine Intervention Related Signaling Pathways

心肌梗死后心力衰竭(Heart Failure After Myocardial Infarction, HFAMI)正日益成为全世界医疗行业面临的考验。近年来虽然随着经皮冠状动脉介入术等诊疗心肌梗死的技术的不断进步，急性心梗(Acute Myocardial Infarction, AMI)患者的住院死亡率已降低，但AMI导致的心力衰竭发病率正不断上升。目前西医在防治HFAMI上所取得的成果仍有限，主要以使用利尿剂、正性肌力药、血管活性药物、神经内分泌激素调节剂等药物对症治疗，缺乏改善远期预后的方法。中医药在防治HFAMI方面有其独特优势，临床上通过方剂、中药制剂、针灸等治疗方式，可以改善HFAMI患者的生活质量及远期预后。当前中医药防治HFAMI涉及多种机制的干预，这些机制参与了HFAMI患者心室重构过程。此文通过对中医药干预机制治疗HFAMI进行综述，为阐明中医药靶向治疗HFAMI的研究提供参考。Heart failure after myocardial infarction (HFAMI) is increasingly becoming a challenge in the global medical industry. In recent years, although the technology for diagnosing and treating myocardial infarction, such as percutaneous coronary intervention, has advanced, the incidence of heart failure following acute myocardial infarction (AMI) continues to rise. Western medicine has achieved limited success in the prevention and treatment of HFAMI, primarily using diuretics, positive inotropic drugs, vasodilators, and neurohormonal regulators to alleviate symptoms, but lacking methods for improving long-term prognosis. Traditional Chinese medicine (TCM) has unique advantages in preventing and treating HFAMI. Through prescriptions, herbal preparations, acupuncture, and other treatment methods, TCM can improve the quality of life and long-term prognosis of HFAMI patients. Currently, TCM interventions for HFAMI involve multiple mechanisms that are involved in ventricular remodeling in HFAMI patients. This article provides a review of the mechanisms by which TCM intervention treats HFAMI, serving as a reference for targeted TCM treatment of HFAMI.