Key result
Combined systolic-diastolic and isolated diastolic hypertension were associated with higher rates of carotid plaque (12 of 15 and 14 of 31, respectively) compared to isolated systolic hypertension (1 of 30).
Why the study?
Are specific subtypes of hypertension associated with a higher burden of subclinical atherosclerosis compared to normotensive individuals?
Cross-Sectional (n=96)
No
Are specific subtypes of hypertension associated with a higher burden of subclinical atherosclerosis compared to normotensive individuals?
Isolated diastolic hypertension and combined systolic-diastolic hypertension are associated with more advanced early subclinical atherosclerosis compared to isolated systolic hypertension.
Answers are grounded in this paper and cite their sources.
Hypertension subtype associations with carotid plaque warrant no practice change; leaves open whether subtype-targeted screening improves outcomes in prospective studies.
OBJECTIVES: To assess subclinical atherosclerosis in subtypes of hypertension using lipid profile as a biomarker and B mode ultrasonography of the carotid arteries. METHODS: Ninety-six subjects (49 females and 47 males) aged 42-78 years were recruited from the vascular Doppler unit at Baghdad Teaching Hospital, Baghdad, Iraq from January to June 2008. They were grouped into normotensive (group I), isolated systolic hypertension (group II), isolated diastolic hypertension (group III), and combined systolic and diastolic hypertension (group IV). RESULTS: Subclinical atherosclerosis was observed in groups III and IV in terms of significantly low levels of high-density lipoprotein, high levels of low-density lipoprotein, and high atherogenic index. The mean intima media thickness was significantly increased with transition from group I to group IV in all carotid arteries, and the mean resistive index value of each carotid artery in group IV was significantly higher than that of group I. Carotid plaque was demonstrated in a significantly higher percent in group IV (12 out of 15) followed by groups III (14 out of 31) and II (1 out of 30). CONCLUSION: Lipid profile and high resolution B-mode ultrasonography of the carotids are good predictive measures of subclinical atherosclerosis. Isolated diastolic hypertension and combined systolic-diastolic hypertension accounts for early subclinical atherosclerosis compared with isolated systolic hypertension.
No takes yet. Share an insight, caveat, or question.
Al-Nimer et al. (2010) conducted a cross-sectional in Hypertension (n=96). Hypertension subtypes (isolated diastolic and combined systolic-diastolic) vs. Normotension and isolated systolic hypertension was evaluated on Subclinical atherosclerosis (carotid plaque, intima media thickness, and lipid profile). Combined systolic-diastolic and isolated diastolic hypertension were associated with higher rates of carotid plaque (12 of 15 and 14 of 31, respectively) compared to isolated systolic hypertension (1 of 30).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: