Key result
Enteroviruses can be transmitted between cells as populations of viral particles enclosed in vesicles, significantly enhancing infection efficiency compared to free viral particles.
This review highlights a novel mechanism of viral transmission via vesicles that enhances infection efficiency and may be widespread among virus families.
Enteroviral vesicular transmission may boost infection efficiency; leaves open extension to other viruses and therapeutic relevance.
A common paradigm holds that during cell-to-cell transmission, viruses behave as lone soldiers. Recently, we discovered not only that enteroviruses are transmitted via vesicles as populations of viral particles but also that this type of transmission enhances their infection efficiency (Y. H. Chen et al., Cell 160: 619-630, 2015). This mechanism could be advantageous for the overall fitness of the viral population, promoting genetic interplay by enabling viral quasispecies to collectively infect a susceptible host cell. Here, we discuss these findings in the context of viral pathogenesis and also propose that this novel type of vesicular transmission is widespread among different virus families and includes populations of both viral particles and naked viral genomes.
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Altan‐Bonnet et al. (2015) conducted a review in Enterovirus infection. Vesicular transmission of viral populations vs. Transmission of free viral particles was evaluated. Enteroviruses can be transmitted between cells as populations of viral particles enclosed in vesicles, significantly enhancing infection efficiency compared to free viral particles.
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