Key result
Fatty liver was associated with an increased prevalence of carotid intima-media thickening but a decreased prevalence of plaques, with age acting as an independent predictor of carotid disease.
Observational (n=449)
Cardiovascular risk assessment in patients with fatty liver and NAFLD should consider age and body weight, as fatty liver is associated with earlier carotid disease but may be protective against plaques.
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Fatty liver may warrant age-adjusted carotid evaluation in NAFLD; leaves open whether associations reflect true differential atherosclerosis risk.
AIM: To evaluate carotid intima-media thickening (IMT) and plaques, gallstone disease (GD) and fatty liver (FL) as a function of age. METHODS: In 449 subjects, FL and carotid disease were assessed ultrasonographically. In a subgroup of 65/449 patients with non-alcoholic fatty liver disease (NAFLD), carotid disease, GD and associated factors were determined. RESULTS: FL of unspecified etiology was more common in younger and GD in older individuals. FL subjects had an increased prevalence of IMT and a decreased prevalence of plaques and manifested carotid disease earlier. Plaques were more common in subjects with GD. Age was an independent predictor of carotid disease outcome and FL was a protective factor for plaques. In NAFLD, there was an inverse correlation between body weight and age and the latter independently predicted carotid findings. CONCLUSION: Cardiovascular risk in patients with FL and NAFLD needs to be assessed as a function of age and body weight.
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Amedeo Lonardo (2006) conducted an observational in Fatty liver, carotid disease, and gallstones (n=449). Fatty liver vs. Absence of fatty liver was evaluated on Carotid intima-media thickening and plaques. Fatty liver was associated with an increased prevalence of carotid intima-media thickening but a decreased prevalence of plaques, with age acting as an independent predictor of carotid disease.
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