Editorials7 March 2006The Growing Menace of Community-Acquired Methicillin-Resistant Staphylococcus aureusRobert C. Moellering Jr., MDRobert C. Moellering Jr., MDFrom Beth Israel Deaconess Medical Center, Boston, MA 02215.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-5-200603070-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail As we read anxiously about the possibility of a worldwide pandemic of avian influenza, another epidemic is actually happening in the United States and elsewhere. Methicillin-resistant strains of Staphylococcus aureus (MRSA) have now emerged as community-acquired pathogens capable of causing serious disease. We have known about MRSA since the early 1960s (1). Until recently, however, infection with these strains was primarily limited to hospitals and other institutional settings. Sporadic reports of community-acquired (or community-associated) MRSA infections have appeared since 1980, but 1999 marked the beginning of the current epidemic in the United States. The sentinel event was a series of ...References1. Lowy FD. Staphylococcus aureus infections. N Engl J Med. 1998;339:520-32. [PMID: 9709046] CrossrefMedlineGoogle Scholar2. Rybak MJ, LaPlante KL. Community-associated methicillin-resistant Staphylococcus aureus: a review. Pharmacotherapy. 2005;25:74-85. [PMID: 15767223] CrossrefMedlineGoogle Scholar3. King MD, Humphrey BJ, Wang YF, Kourbatova EV, Ray SM, Blumberg HM. Emergence of community-acquired methicillin-resistant Staphylococcus aureus USA 300 clone as the predominant cause of skin and soft-tissue infections. Ann Intern Med. 2006;144:309-17. LinkGoogle Scholar4. Kaplan SL, Hulten KG, Gonzalez BE, Hammerman WA, Lamberth L, Versalovic J, et al. Three-year surveillance of community-acquired Staphylococcus aureus infections in children. Clin Infect Dis. 2005;40:1785-91. [PMID: 15909267] CrossrefMedlineGoogle Scholar5. Naimi TS, LeDell KH, Como-Sabetti K, Borchardt SM, Boxrud DJ, Etienne J, et al. Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection. JAMA. 2003;290:2976-84. [PMID: 14665659] CrossrefMedlineGoogle Scholar6. Baba T, Takeuchi F, Kuroda M, Yuzawa H, Aoki K, Oguchi A, et al. Genome and virulence determinants of high virulence community-acquired MRSA. Lancet. 2002;359:1819-27. [PMID: 12044378] CrossrefMedlineGoogle Scholar7. Chambers HF. Community-associated MRSA—resistance and virulence converge [Editorial]. N Engl J Med. 2005;352:1485-7. [PMID: 15814886] CrossrefMedlineGoogle Scholar8. Banthia S, Meka VG, Pillai S, Wener K, Freedman R, Pandya S, et al. A fatal case of necrotizing pneumonia caused by community-associated methicillin-resistant Staphylococcus aureus. Infectious Diseases in Clinical Practice. 2005;13:132-8. CrossrefGoogle Scholar9. Gonzalez BE, Hulten KG, Dishop MK, Lamberth LB, Hammerman WA, Mason EO, et al. Pulmonary manifestations in children with invasive community-acquired Staphylococcus aureus infection. Clin Infect Dis. 2005;41:583-90. [PMID: 16080077] CrossrefMedlineGoogle Scholar10. Miller LG, Perdreau-Remington F, Rieg G, Mehdi S, Perlroth J, Bayer AS, et al. Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles. N Engl J Med. 2005;352:1445-53. [PMID: 15814880] CrossrefMedlineGoogle Scholar11. Adem PV, Montgomery CP, Husain AN, Koogler TK, Arangelovich V, Humilier M, et al. Staphylococcus aureus sepsis and the Waterhouse-Friderichsen syndrome in children. N Engl J Med. 2005;353:1245-51. [PMID: 16177250] CrossrefMedlineGoogle Scholar12. Francis JS, Doherty MC, Lopatin U, Johnston CP, Sinha G, Ross T, et al. Severe community-onset pneumonia in healthy adults caused by methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin genes. Clin Infect Dis. 2005;40:100-7. [PMID: 15614698] CrossrefMedlineGoogle Scholar13. Graham PL, Lin SX, Larson EL. A U.S. population-based survey of Staphylococcus aureus colonization. Ann Intern Med. 2006;144:318-25. LinkGoogle Scholar14. Boyce JM, Havill NL, Maria B. Frequency and possible infection control implications of gastrointestinal colonization with methicillin-resistant Staphylococcus aureus. J Clin Microbiol. 2005;43:5992-5. [PMID: 16333087] CrossrefMedlineGoogle Scholar15. van Duijkeren E, Wolfhagen MJ, Heck ME, Wannet WJ. Transmission of a Panton-Valentine leucocidin-positive, methicillin-resistant Staphylococcus aureus strain between humans and a dog. J Clin Microbiol. 2005;43:6209-11. [PMID: 16333133] CrossrefMedlineGoogle Scholar16. Healy CM, Hulten KG, Palazzi DL, Campbell JR, Baker CJ. Emergence of new strains of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit. Clin Infect Dis. 2004;39:1460-6. [PMID: 15546082] CrossrefMedlineGoogle Scholar17. Siberry GK, Tekle T, Carroll K, Dick J. Failure of clindamycin treatment of methicillin-resistant Staphylococcus aureus expressing inducible clindamycin resistance in vitro. Clin Infect Dis. 2003;37:1257-60. [PMID: 14557972] CrossrefMedlineGoogle Scholar18. Gauduchon V, Cozon G, Vandenesch F, Genestier AL, Eyssade N, Peyrol S, et al. Neutralization of Staphylococcus aureus Panton Valentine leukocidin by intravenous immunoglobulin in vitro. J Infect Dis. 2004;189:346-53. [PMID: 14722901] CrossrefMedlineGoogle Scholar19. Highlander S, Hulten K, Yerrapragada S, Quin X, Jiang H, Mason E, et al. Genome sequence of Staphylococcus aureus USA300, a dominant community-acquired MRSA [Abstract]. In: Abstracts of 45th Interscience Conference of Antimicrobial Agents and Chemotherapy, Washington, DC, 16–19 December 2005. Abstract no. LB2-17. Google Scholar Author, Article, and Disclosure InformationAuthors: Robert C. MoelleringJr., MDAffiliations: From Beth Israel Deaconess Medical Center, Boston, MA 02215.Disclosures: Consultancies: R.C. Moellering (Pfizer Inc., Cubist Pharmaceuticals); Honoraria: R.C. Moellering (Pfizer Inc., Cubist Pharmaceuticals); Grants received: R.C. Moellering (Pfizer Inc., Cubist Pharmaceuticals).Corresponding Author: Robert C. Moellering Jr., MD, Department of Medicine, Beth Israel Deaconess Medical Center, 110 Francis Street, Suite 6A, Boston, MA 02215. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEmergence of Community-Acquired Methicillin-Resistant Staphylococcus aureus USA 300 Clone as the Predominant Cause of Skin and Soft-Tissue Infections Mark D. King , Bianca J. Humphrey , Yun F. Wang , Ekaterina V. 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Blumberg, MD, Susan M. Ray, MD, and Mark D. King, MD, MScPotential Consequences of the Pneumococcal Conjugate VaccineCarriage of methicillin‐resistant Staphylococcus aureus in a Queensland Indigenous community 7 March 2006Volume 144, Issue 5Page: 368-370KeywordsAbscessesAntimicrobialsChildrenClindamycinEpidemiologyMethicillin-resistant staphylococcus aureusPediatric infectionsPopulation statisticsSkin infectionsToxins ePublished: 7 March 2006 Issue Published: 7 March 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
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