Key result
Propofol combined with fentanyl yielded a higher total response rate (98% vs 90%, P<0.05) and fewer adverse reactions (6% vs 18%) than propofol alone during gastrointestinal endoscopy.
Why the study?
Sufficient doses of propofol or fentanyl to prevent response to skin incision do not necessarily reduce hemodynamic responses, so the study characterized their pharmacodynamic interaction regarding sedative effects and safety.
Does fentanyl combined with propofol improve sedation efficacy and safety compared to propofol alone in patients undergoing painless gastrointestinal endoscopy?
Population
200 patients undergoing painless gastrointestinal endoscopy
Comparison
Fentanyl intravenous injection followed by propofol vs propofol alone
Design
Randomized controlled trial
Authors
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May warrant caution with propofol-fentanyl dosing in endoscopy; leaves open optimal regimens for hemodynamic stability.
RCT (n=200)
randomly divided
No
Does fentanyl combined with propofol improve sedation efficacy and safety compared to propofol alone in patients undergoing painless gastrointestinal endoscopy?
Absolute Event Rate: 98% vs 90%
p-value: p=< 0.05
Combining fentanyl with propofol for gastrointestinal endoscopy sedation improves response rates, reduces adverse reactions, and lowers the required propofol dose compared to propofol alone.
Chang et al. (2021) conducted an RCT in painless gastrointestinal endoscopy (n=200). Propofol combined with fentanyl vs. Propofol alone (100 mg/min) was evaluated on total response rate (p=< 0.05). Propofol combined with fentanyl yielded a higher total response rate (98% vs 90%, P<0.05) and fewer adverse reactions (6% vs 18%) than propofol alone during gastrointestinal endoscopy.
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