We suggest that aggressive clinical tumor behavior correlates with the presence of squamous differentiation and with irregularities in the peripheral palisading of basal cell carcinomas. The concept of non-melanoma skin cancer being a basosquamous continuum may help in formulating a method for prognosis in patients who had removed tumors with a pathologist's report of a "positive margin."
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A. Lee Dellon (1978) studied this question.