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March 11, 2022Frontiers in PediatricsOpen Access

Association Between Neonatal Arrhythmia and Mortality and Recurrence: A Retrospective Study

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Key result

Non-benign neonatal arrhythmia was associated with significantly higher rates of death (OR 5.73) and recurrence (OR 8.49) compared to benign neonatal arrhythmia.

Why the study?

The study was conducted to explore the association between neonatal arrhythmia and mortality and recurrence.

Does non-benign neonatal arrhythmia increase the risk of mortality and recurrence compared to benign neonatal arrhythmia in neonates?

Population

179 neonates with neonatal arrhythmia

Comparison

Non-benign neonatal arrhythmia vs benign neonatal arrhythmia

Design

Single-center retrospective study

Follow-up

Within 2 to 6 years

Authors

LRLihong RanNanjing University of Science and TechnologyJLJie LiUniversity of South CarolinaLBLei BaoTianjin University of Sport

Discussion

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Member takes

Implication

Non-benign neonatal arrhythmias may warrant closer surveillance; this Level 3 finding leaves open causal links and intervention effects.

Study Design

Type

Cohort (n=179)

Multicenter

No

Structured PICO

Does non-benign neonatal arrhythmia increase the risk of mortality and recurrence compared to benign neonatal arrhythmia in neonates?

P
Population
179 neonates diagnosed with neonatal arrhythmia within 28 days of life, followed for a median of 39 months to assess mortality and recurrence.
E
Exposure
Non-benign neonatal arrhythmia
C
Comparator
Benign neonatal arrhythmia
O
Outcome
Mortality and recurrence within 2 to 6 yearshard clinical

Main Result

Odds Ratio: 5.73 (95% CI 1.07–31.01)

Absolute Event Rate: 13.79% vs 1.65%

p-value: p=0.04

Non-benign neonatal arrhythmia is associated with significantly higher risks of mortality and recurrence compared to benign neonatal arrhythmia, highlighting the need for close follow-up.

Limitations

  • Relatively small sample size in a single-center study
  • Retrospective design might underestimate the incidence of neonatal arrhythmia, as mild and/or transient cases may not be recorded

Cite This Study

Ran et al. (2022) conducted a cohort in Neonatal arrhythmia (n=179). Non-benign neonatal arrhythmia vs. Benign neonatal arrhythmia was evaluated on Mortality (OR 5.73, 95% CI 1.07-31.01, p=0.04). Non-benign neonatal arrhythmia was associated with significantly higher rates of death (OR 5.73) and recurrence (OR 8.49) compared to benign neonatal arrhythmia.

synapsesocial.com/papers/6a94127bfb64bc8805215599https://doi.org/10.3389/fped.2022.818164
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A case series of neonatal arrhythmias2015 · 17 citations
  2. 2A Case Series of Neonatal Arrhythmias at Multiple Centres in North Maharashtra, India2023
  3. 3Clinical Evaluation of Neonatal Arrhythmias: Experience from a Specialized Pediatric Cardiac Center2026
  4. 4Incidence of non‐benign arrhythmia in neonatal intensive care unit: 18 years experience from a single center2022 · 8 citations
  5. 5A Prospective Evaluation of Arrhythmias in a Large Tertiary Neonatal Intensive Care Unit2022