Key result
Thrombus aspiration combined with intracoronary tirofiban significantly improved TIMI flow grade, TMP grade, and cardiac function, and reduced no/slow reflow rate compared to conventional PCI.
Why the study?
Does thrombus aspiration combined with intracoronary tirofiban improve coronary blood flow and cardiac function in patients undergoing elective PCI during recovery from acute MI?
RCT (n=80)
randomized
Does thrombus aspiration combined with intracoronary tirofiban improve coronary blood flow and cardiac function in patients undergoing elective PCI during recovery from acute MI?
Thrombus aspiration combined with intracoronary tirofiban improves coronary flow and cardiac function in patients undergoing elective PCI after acute MI.
Supports combined thrombus aspiration and intracoronary tirofiban in elective post-MI PCI; extends RCT evidence to the recovery phase.
OBJECTIVE: To compare the efficacy and safety of combined treatment with thrombus aspiration and intracoronary tirofiban in patients with acute myocardial infarction (MI), with elective percutaneous coronary intervention (PCI). METHODS: Patients undergoing elective PCI during recovery from acute MI were randomized into two groups; the intervention group received thrombus aspiration and intracoronary tirofiban; the control group received conventional PCI. Baseline clinical characteristics, postoperative coronary blood flow (thrombolysis in myocardial infarction [TIMI] grade), TIMI myocardial perfusion (TMP) grade, no/slow reflow rate and cardiac function (measured by echocardiography 1 month postoperatively) were evaluated. Major adverse cardiac event rate and bleeding complications during surgery (and at 1 month and 1 year postoperatively) were also evaluated. RESULTS: A total of 80 patients were included. Postoperatively, the number of patients with TIMI flow grade 3 and the mean TMP grade were both significantly higher, and the no/slow reflow rate was significantly lower, in the intervention group versus the control group. Echocardiography indicated that cardiac function was significantly improved in the intervention group compared with the control group. There were no major complications in either study group. CONCLUSION: Thrombus aspiration combined with intracoronary tirofiban during recovery from acute MI was effective and relatively well tolerated.
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Liu et al. (2013) conducted an RCT in acute myocardial infarction (n=80). thrombus aspiration combined with intracoronary tirofiban vs. conventional PCI was evaluated on postoperative coronary blood flow (TIMI grade), TMP grade, no/slow reflow rate and cardiac function. Thrombus aspiration combined with intracoronary tirofiban significantly improved TIMI flow grade, TMP grade, and cardiac function, and reduced no/slow reflow rate compared to conventional PCI.
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